Sodium citrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Citric acid trisodium 是一种天然防腐剂和食品酸味增强剂。Citric acid trisodium 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G2/M 期和 S 期。Citric acid trisodium 通过降低抗氧化酶活性引起肝脏的氧化损伤。Citric acid trisodium 对小鼠造成肾毒性。

Citric acid trisodium is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium causes renal toxicity in mice.

Citric acid trisodium (0-12.5 mM; 24 h) shows antiproliferative activity in a dose dependent manner.Citric acid trisodium (12.5 mM; 72 h) induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner.Citric acid trisodium (12.5 mM; 48 h) increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl..Cell Viability Assay Cell Line:HaCaT cells Concentration:0, 2.5, 5, 7.5, 10, 12.5 mM Incubation Time:24 h Result:Inhibited the cell viability in a dose dependent manner.Cell Cycle Analysis Cell Line:HaCaT cells Concentration:12.5 mM Incubation Time:0, 12, 24, 48, 72 h Result:Induced apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner.Western Blot Analysis Cell Line:HaCaT cells Concentration:12.5 mM Incubation Time:12, 24, 48 h Result:Increased the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreased of BCL-2 and BCL-Xl.

Citric acid trisodium (120, 240, and 480 mg/kg; i.p.) significantly decreases GSH-Px activity and induces an increase in the MDA (malonyldialdehyde) levels in mouse liver.Citric acid trisodium (120, 240, and 480 mg/kg; i.p.) induces apoptosis by increases caspase-3 activity in a dose-dependent manner in mouse hepatocytes.Citric acid trisodium (120, 240, and 480 mg/kg; i.p.; weekly for 3 weeks) causes renal toxicity in mice.Animal Model:20 g male Kunming mice Dosage:120, 240, 480 mg/kg Administration:I.p.; weekly for 3 weeks Result:T-SOD and GSH-Px activities in the treated groups decreased with increasing doses of citric acid, NOS activity tended to increase, and H2O2 and MDA contents gradually decreased.

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Others

Other Targets

Others

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68-04-2

258.07

C6H5Na3O7

>98% (HPLC)

In Vitro:?H2O 中的溶解度 : 50 mg/mL (193.75 mM; 超声助溶)

C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Na+].[Na+].[Na+]

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(-20℃)

With Ice Pack

≥ 2 years